Anti -L1CAM Rabbit pAb

價格：在線咨詢

貨號：

KT011873

產(chǎn)品規(guī)格：

100 μL

Applications：

WB/IHC/IF

Species：

MR/MR/MR

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	L1CAM rabbit polyclonal
Protein full name	Neural cell adhesion molecule L1
Synonyms	NCAM-L1, CD171, L1cam, Caml1, CD171 antigen, HSAS, MASA
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse L1CAM
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cell membrane
Predicted MW.	141 kDa
Observed MW.	141/220 kDa
Uniprot ID	P11627, Q05695

Applications

Applications	Species	Dilution	Positive Tissue
WB	Mouse, Rat	1: 500-1: 1000	brain, cerebral cortex, hippocampus, spinal cord
IHC	Mouse, Rat	1: 1000-1: 4000	thalamus, brain, cerebellum
IF	Mouse, Rat	1: 500-1: 1000	thalamus, brain, cerebellum

Background

The protein encoded by L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of L1CAM results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

Images

Western blot analysis of L1CAM (GB111004) at dilution of 1: 1000

Lane 1: Mouse brain tissue lysate

Lane 2: Mouse cerebral cortex tissue lysate

Lane 3: Mouse hippocampus tissue lysate

Lane 4: Mouse spinal cord tissue lysate

Lane 5: Rat brain tissue lysate

Lane 6: Rat cerebral cortex tissue lysate

Lane 7: Rat hippocampus tissue lysate

Immunohistochemistry analysis of paraffin-embedded mouse thalamus using L1CAM (GB111004) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded rat cerebellum using L1CAM (GB111004) at dilution of 1: 2000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer.

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