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Anti -AKT1 Rabbit pAb

價格: 在線咨詢
貨號:
KT012268
產(chǎn)品規(guī)格:
100ul
Applications:
WB
Species:
H/M/R
購買數(shù)量:
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Product Information


Description

AKT1 rabbit polyclonal antibody

Protein full name

RAC-alpha serine/threonine-protein kinase

Synonyms

AKT1 kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, Akt1, Thymoma viral proto-oncogene, Akt

Immunogen

KLH conjugated Synthetic peptide corresponding to Rat AKT1

Isotype

IgG

Purity

Affinity purification

Predicted MW.

56 kDa

Observed MW.

60 kDa

Uniprot ID

P31749, P31750, P47196



Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1500

heart, brain




Background


The AKT1 protein plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4.This protein is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.




Images


Picture 1.png

Western blot analysis of AKT1 at dilution of 1: 500





Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


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