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Anti -TANK/TRAF2 Rabbit pAb

價(jià)格: 在線咨詢
貨號(hào):
KT012185
產(chǎn)品規(guī)格:
Applications:
WB | IHC | IF
Species:
M,R/H
購(gòu)買數(shù)量:
產(chǎn)品詳情 操作說(shuō)明 注意事項(xiàng)

Product Information


Description

TANK/TRAF2 rabbit polyclonal antibody

Protein full name

TRAF family member-associated NF-kappa-B activator

Synonyms

TRAF-interacting protein, I-TRAF, Tank, Itraf

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse TRAF2

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm

Predicted MW.

51 kDa

Observed MW.

45 kDa

Uniprot ID

Q92844, P70347




Applications


Applications

Species

Dilution

Positive Sample

WB

Mouse, Rat

1: 500-1: 1000

brain, heart

IHC/IF

Human

1: 500-1: 1000

colon cancer, kidney, liver cancer, lung




Background


Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity.




Images


Picture 1.png

Western blot analysis of ITRAF (GB112338) at dilution of 1: 500

Picture 2.png Immunofluorescence of paraffin embedded human colon cancer using ITRAF (GB112338) at dilution of 1: 600 (400x lens)

Picture 3.png

Immunofluorescence of paraffin embedded human kidney using ITRAF (GB112338) at dilution of 1: 600 (400x lens)

Picture 4.png

Immunofluorescence of paraffin embedded human liver cancer using ITRAF (GB112338) at dilution of 1: 600 (400x lens)

Picture 5.png

Immunofluorescence of paraffin embedded human lung using ITRAF (GB112338) at dilution of 1: 600 (400x lens)




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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