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Anti -TLS/FUS Rabbit pAb

價(jià)格: 在線咨詢
貨號(hào):
KT012113
產(chǎn)品規(guī)格:
100ul
Applications:
IHC/IF
Species:
M
購(gòu)買數(shù)量:
產(chǎn)品詳情 操作說(shuō)明 注意事項(xiàng)

Product Information

Description

FUS rabbit polyclonal antibody

Protein full name

RNA-binding protein FUS

Synonyms

Protein pigpen, Fus, 75 kDa DNA pairing protein, ALS6, FUS CHOP, FUS1, POMp75, Fusion (involved in t(12;16) in malignant liposarcoma), hnRNP P2, Fusion gene in myxoid liposarcoma, Heterogeneous nuclear ribonucleoprotein P2, Oncogene TLS

Immunogen

Recombinant protein corresponding to Mouse FUS

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P56959





Applications

Applications

Species

Dilution

Positive Sample

IHC/IF

Mouse

1: 800-1: 2000

brain, pancreas, Skeletal muscle





Background

FUS (also named TLS and POMp75) belongs to the RRM TET family. FUS may play a role in the maintenance of genomic integrity; it binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. FUS is also an RNA-binding protein, and its links to neurodegenerative disease proffer the intriguing possibility that altered RNA metabolism or RNA processing may underlie or contribute to neuron degeneration. FUS may be a cause of angiomatoid fibrous histiocytoma (AFH) and is implicated in certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementias (FTDs) such as frontotemporal lobar dementia with ubiquitin inclusions (FTLD-U).





Images

Immunofluorescence of paraffin embedded mouse brain using FUS (GB111365) at dilution of 1:1000 (400x lens)

Immunofluorescence of paraffin embedded mouse pancreas using FUS (GB111365) at dilution of 1:1000 (400x lens)

Immunofluorescence of paraffin embedded mouse Skeletal muscle using FUS (GB111365) at dilution of 1:1000 (400x lens)





Storage

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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