Anti -Osteoprotegerin Rabbit pAb

價(jià)格：在線咨詢

貨號：

KT012052

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

M/R

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Osteoprotegerin rabbit polyclonal antibody
Protein full name	Tumor necrosis factor receptor superfamily member 11B
Synonyms	TNFRSF11B, OCIF, OPG, PDB5, TR1, tumor necrosis factor receptor superfamily member 11b, TNF receptor superfamily member 11b
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Osteoprotegerin
Isotype	IgG
Purity	Affinity purification
Subcellular location	Secreted
Uniprot ID	O08712, O08727

Applications

Applications	Species	Dilution	Positive Sample
IHC/IF	Mouse, Rat	1: 100-1: 400	bone

Background

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Images

Immunohistochemistry of paraffin embedded mouse bone using OPG (GB11151) at dilution of 1:200 (100x lens)

Immunohistochemistry of paraffin embedded rat bone using OPG (GB11151) at dilution of 1:200 (100x lens)

Picture 3.png

Immunofluorescence of paraffin embedded mouse bone using OPG (GB11151) at dilution of 1:100 (100x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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