Anti -IDH1 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

KT012029

產(chǎn)品規(guī)格：

100ul

Applications：

Species：

H/M/R

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	IDH1 rabbit polyclonal antibody
Protein full name	Isocitrate dehydrogenase [NADP] cytoplasmic
Synonyms	Cytosolic NADP-isocitrate dehydrogenase, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, IDH1, Idh1
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse IDH1
Isotype	IgG
Purity	Affinity purification
Predicted MW.	47 kDa
Observed MW.	47 kDa
Uniprot ID	O75874, O88844, P41562

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Mouse, Rat	1: 500-1: 1000	liver, kidney, stomach

Background

The Isocitrate dehydrogenase cytoplasmic enzyme belongs to the isocitrate and isopropylmalate dehydrogenases family. IDHC catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ketoglutarate and CO2 in a two step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Ca2+ can bind to IDHC as a complex with isocitrate, acting as a competitive inhibitor of Mg2+. The IDHC enzyme is inactivated by phosphorylation at Ser-113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock.

Images

Picture 1.png

Western blot analysis of IDH1 (GB111194) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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