Anti -MRP1 Rabbit pAb

價格：在線咨詢

貨號：

KT012015

產(chǎn)品規(guī)格：

100ul

Applications：

IHC/IF

Species：

R/R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	MRP1 rabbit polyclonal
Protein full name	Multidrug resistance-associated protein 1
Synonyms	ATP-binding cassette sub-family C member 1, Leukotriene C(4) transporter, Abcc1, Mrp1, LTC4 transporter
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse MRP1
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cell membrane
Uniprot ID	Q8CG09

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Rat	1: 800-1: 1600	lymphoid, brain
IF	Rat	1: 400-1: 800	lymphoid, brain

Background

MRP1 is a member of the MRP subfamily of ATPbindingcassette (ABC) transporters . MRP1 protein functions as an organic anion transporter. It has a broad range of substrates, including antineoplastic or therapeutic agent sand the glutathione (GSH) conjugates of these compounds. MRP1 also transports physiological substrates such as folates, GSH and GSH disulfide (GSSG) conjugates of steroids,leukotrienes and prostaglandins. Although MRP1 is generally expressed in normaltissue, upregulation of MRP1 has been found in avariety of solid tumors, including small cell lung cancer, breast cancer, and prostate cancer . Research studies show that over expression of MRP1 facilitates the elimination of therapeutic agents from cancer cells and confers drug resistance in those patients. Research studies also show that elevated expression of MRP1 is a negative prognostic marker for breast cancer and small cell lung cancer, as the level of MRP1 is predictive of the response and toxicity of chemotherapeutic agents in those patients.

Images

	Immunohistochemistry analysis of paraffin-embedded rat lymphoid usingMRP1 (GB111041) at dilution of 1: 1600
	Immunohistochemistry analysis of paraffin-embedded rat brain using MRP1 (GB111041) at dilution of 1: 1600

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer.

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