Anti -VCP Rabbit pAb

價格：在線咨詢

貨號：

KT011915

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項

Product Information

Description	VCP rabbit polyclonal antibody
Protein full name	Transitional endoplasmic reticulum ATPase
Synonyms	TER ATPase, 15S Mg(2+)-ATPase p97 subunit, Valosin-containing protein, VCP
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse VCP
Isotype	IgG
Purity	Affinity purification
Predicted MW.	89 kDa
Observed MW.	97 kDa
Uniprot ID	P55072, Q01853

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Mouse	1: 500-1: 1000	brain, lung

Background

Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinson's Disease. VCP has a calculated molecular weight of 89 kDa and an apparent molecular weight of 90-100 kDa.

Images

Western blot analysis of VCP (GB111155) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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