Anti -HtrA2 / Omi Rabbit pAb

價格：在線咨詢

貨號：

KT011725

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項

Product Information

Description	HtrA2 rabbit polyclonal antibody
Protein full name	Serine protease HTRA2, mitochondrial
Synonyms	High temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, HtrA like serine protease, HtrA serine peptidase 2, Serine protease htra2 mitochondrial precursor, PARK 13, Protease serine 25, Serine p
Immunogen	Recombinant protein corresponding to Mouse HtrA2
Isotype	IgG
Purity	Affinity purification
Predicted MW.	49 kDa
Observed MW.	39 kDa
Uniprot ID	O43464

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human	1: 500- 1: 1000	293T, HeLa, MCF7

Background

This (HtrA2)/Omi is a serine protease with homology to the E.coli HtrA protein (DegP) and is thought to be involved inapoptosis and stress induced degradation of misfolded proteins. While HtrA2 was orignally identified to bepresent in either the nucleus or endoplasmic reticulum, subsequent studies have shown that it localizes in mitochondria and is released during apoptosis. HtrA2 is produced as a 50 kDa zymogen that is cleaved to generate a 36 kDa mature protein that exposes an amino terminal motif (AVPS) resembling that of the IAP inhibitor Smac/Diablo. research studies have shown that loss of function mutations in the HtrA2 gene are associated with Parkinson’s disease.

Images

Western blot analysis of htar2 (GB11982) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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