Anti -Pin1 Rabbit pAb

價(jià)格：在線咨詢

貨號：

KT011512

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

H,M,R

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Pin1 rabbit polyclonal antibody
Protein full name	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms	Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, Pin1
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Pin1
Isotype	IgG
Purity	Affinity purification
Predicted MW.	18 kDa
Observed MW.	18 kDa
Uniprot ID	Q13526, Q9QUR7, B0BNL2

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Mouse, Rat	1: 300-1: 800	spleen, testis

Background

Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds.Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.

Images

Western blot analysis of PIN1 (GB111193) at dilution of 1: 300

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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