Anti -BPTF / FALZ Rabbit pAb

價(jià)格：在線咨詢

貨號：

KT011514

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

H,M,R

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	BPTF rabbit polyclonal antibody
Protein full name	Nucleosome-remodeling factor subunit BPTF
Synonyms	Bromodomain and PHD finger-containing transcription factor, Fetal Alz-50 clone 1 protein, Fetal Alzheimer antigen, BPTF, FAC1, FALZ
Immunogen	Recombinant protein corresponding to Human BPTF
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus, Cytoplasm
Uniprot ID	Q12830

Applications

Applications	Species	Dilution	Positive Tissue
IHC/IF	Human, Mouse, Rat	1:500-1:1000	brain, colon cancer, liver, testis

Background

FALZ/BPTF is a histone-binding component of NURF (nucleosome remodeling factor), a complex that catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. This gene was identified in brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), containing a DNA-binding domain, a zinc finger motif, and a C-terminal bromodomain, suggested it might play a role in the regulation of transcription during proliferation. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. This protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription.

Images

	Immunohistochemistry of paraffin embedded human colon cancer using BPTF (GB111201) at dilution of 1:500 (400x lens)
	Immunohistochemistry of paraffin embedded mouse brain using BPTF (GB111201) at dilution of 1:500 (400x lens)
	Immunohistochemistry of paraffin embedded mouse testis using BPTF (GB111201) at dilution of 1:1000 (400x lens)
	Immunohistochemistry of paraffin embedded rat brain using BPTF (GB111201) at dilution of 1:500 (400x lens)
	Immunohistochemistry of paraffin embedded rat liver using BPTF (GB111201) at dilution of 1:500 (400x lens)
	Immunohistochemistry of paraffin embedded rat testis using BPTF (GB111201) at dilution of 1:1000 (400x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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