Anti -Securin Rabbit pAb

價格：在線咨詢

貨號：

KT011701

產(chǎn)品規(guī)格：

Applications：

WB | IHC | IF

Species：

M,R | H,M,R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	Securin rabbit polyclonal antibody
Protein full name	Securin
Synonyms	Pituitary tumor-transforming gene 1 protein, Pttg1, Pttg, Cut2, EAP1, ESP1, TUTR1
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Securin
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus, Cytoplasm
Predicted MW.	22 kDa
Observed MW.	26 kDa
Uniprot ID	O95997, Q9CQJ7, P97613

Applications

Applications	Species	Dilution	Positive Sample
WB	Mouse, Rat	1: 500-1: 1000	testis, cecum, skin, epityphlon
IHC/IF	Human, Mouse, Rat	1: 500-1: 2800	placenta, testis

Background

PTTG1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The protein has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. This protein contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus.

Images

	Western blot analysis of Securin (GB111047) at dilution of 1: 500
	Immunohistochemistry of paraffin embedded mouse placenta using Securin (GB111047) at dilution of 1: 1400 (400x lens)
	Immunohistochemistry of paraffin embedded rat testis using Securin (GB111047) at dilution of 1: 1400 (400x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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