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Anti -SHP2 Rabbit pAb

價(jià)格: 在線咨詢
貨號(hào):
KT011669
產(chǎn)品規(guī)格:
100 μL
Applications:
IHC/IF
Species:
R/R
購(gòu)買(mǎi)數(shù)量:
產(chǎn)品詳情 操作說(shuō)明 注意事項(xiàng)

Product Information


Description

SHP2 rabbit polyclonal

Protein full name

Tyrosine-protein phosphatase non-receptor type 11

Synonyms

SHP2, PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, Protein tyrosine phosphatase, non-receptor type 11

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse SHP2

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P35235




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Rat

1: 1000-1: 2000

lung, colon

IF

Rat

1: 500-1: 1000

lung, colon




Background


PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.




Images



image.png


Immunohistochemistry analysis of paraffin-embedded rat lung using

SHP2 (GB11698) at dilution of 1: 1000


image.png

Immunohistochemistry analysis of paraffin-embedded rat colon using

SHP2 (GB11698) at dilution of 1: 1000





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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