Anti -HMGB1 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

KT012135

產(chǎn)品規(guī)格：

100 μL

Applications：

WB/IHC/IF

Species：

HMR/HMR

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	HMGB1 rabbit polyclonal antibody
Protein full name	High mobility group protein B1
Synonyms	HMGB1, HMG1, HMG3, SBP-1, HMG-1, high mobility group box 1
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse HMGB1
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus, Cytoplasm, Secreted, Cell membrane
Predicted MW.	25 kDa
Observed MW.	25 kDa
Uniprot ID	P09429, P63158, P63159

Applications

Applications	Species	Dilution	Positive Sample
WB	Human, Mouse, Rat	1: 500-1: 1000	nasopharyngeal carcinoma, liver, cancer, kidney, colon cancer
IHC/IF	Human, Mouse, Rat	1: 300-1: 3000	brain, breast cancer, colon cancer, kidney, skin, spinal cord

Background

Like the histones, HMGB1 is among the most important chromatin proteins. In the nucleus HMGB1 interacts withnucleosomes, transcription factors, and histones. This nuclear protein organizes the DNA and regulates transcription.After binding, HMGB1 bendsDNA, which facilitates the binding of other proteins. HMGB1 supports transcription of many genes in interactions with many transcription factors. It also interacts with nucleosomes to loosen packed DNA and remodel the chromatin. Contact with core histones changes the structure of nucleosomes.

Images

	Western blot analysis of HMGB1 (GB11103) at dilution of 1: 500
	Immunohistochemistry of paraffin embedded human breast cancer using HMGB1 (GB11103) at dilution of 1: 3000 (300x lens)
	Immunohistochemistry of paraffin embedded human breast cancer using HMGB1 (GB11103) at dilution of 1: 3000 (300x lens)
	Immunohistochemistry of paraffin embedded mouse brain using HMGB1 (GB11103) at dilution of 1: 3000 (300x lens)
	Immunohistochemistry of paraffin embedded mouse kidney using HMGB1 (GB11103) at dilution of 1: 3000 (300x lens)
	Immunohistochemistry of paraffin embedded rat skin using HMGB1 (GB11103) at dilution of 1: 2000 (300x lens)
	Immunohistochemistry of paraffin embedded rat spinal cord using HMGB1 (GB11103) at dilution of 1: 2000 (300x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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