Anti -NFAT4/NF-ATc3 Rabbit pAb

價格：在線咨詢

貨號：

KT012133

產(chǎn)品規(guī)格：

100ul

Applications：

IHC/IF

Species：

H/H

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	NFAT4/NF-ATc3 rabbit polyclonal
Protein full name	Nuclear factor of activated T-cells, cytoplasmic 3
Synonyms	NFATc3, NFATx, T-cell transcription factor NFAT4, NF-AT4, NF-AT4c, NFATC3
Immunogen	Recombinant protein corresponding to Mouse NFAT4/NF-ATc3
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm, Nucleus
Uniprot ID	Q12968

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Human	1: 500-1: 2000	colon cancer
IF	Human	1: 250-1: 500	colon cancer

Background

NFATC3 (nuclear factors of activated T cells) proteins are a family of transcription factors originally identified as mediators of activation of cytokine genes in response to antigenic stimulation of T cells.NFATC3 is widely expressed being found in DP thymocytes, CD4+ T cells, smooth muscle cells, Schwann cells and mast cells. NFATC3 regulates gene transcription as part of a NFATC transcription complex. It is normally cytoplasmic and phosphorylated. Upon a rise in intracellular Ca+2, dephosphorylation occurs via calcineurin, and NFATC3 enters the nucleus. Human NFATC3 is 1075 amino acids in length. It contains a calcineurin binding site (aa 109?114), two nuclear localization sites (aa 273?275 and 686?688), one nuclear export site (a 1032?1041) and an RH domain that binds DNA (aa 433?592). There are multiple isoforms with different tissue expression profiles. Over a 900?1035, human NFATC3 shares 93% a identity with mouse NFATC3. The calculated molecular weight of NFATC3 is 115 kDa, but the post-modified protein is about 130-170 kDa .

Images

Immunohistochemistry analysis of paraffin-embedded human colon cancer using NFAT4/NF-ATc3 (GB111028) at dilution of1: 1000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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