Anti -Clusterin Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

KT012049

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC

Species：

M,R

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Clusterin rabbit polyclonal antibody
Protein full name	Clusterin
Synonyms	Apolipoprotein J, Apo-J, Clustrin, Sulfated glycoprotein 2, SGP-2, Apoj, Clu
Immunogen	Recombinant protein corresponding to Mouse Clusterin
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm, Nucleus, Secreted
Uniprot ID	Q06890, P05371

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1: 500-1: 1500	lung, ovary, pancreas

Background

The Clusterin functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins (By similarity).When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Modulates NF-kappa-B transcriptional activity. Following stress, promotes apoptosis . Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. Following ER stress, suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. When secreted, does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity.

Images

	Immunohistochemistry of paraffin embedded mouse lung using clusterin (GB111144) at dilution of 1:900 (400x lens)
	Immunohistochemistry of paraffin embedded mouse ovary using clusterin (GB111144) at dilution of 1:900 (400x lens)
	Immunohistochemistry of paraffin embedded mouse pancreas using clusterin (GB111144) at dilution of 1:900 (400x lens)
	Immunohistochemistry of paraffin embedded rat lung using clusterin (GB111144) at dilution of 1:900 (400x lens)
	Immunohistochemistry of paraffin embedded rat pancreas using clusterin (GB111144) at dilution of 1:900 (400x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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