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Anti -Nanos3 Rabbit pAb

價格: 在線咨詢
貨號:
KT011806
產(chǎn)品規(guī)格:
100 μL
Applications:
WB
Species:
M/R
購買數(shù)量:
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產(chǎn)品詳情 操作說明 注意事項(xiàng)

Product Information


Description

Nanos3 rabbit polyclonal antibody

Protein full name

Nanos homolog 3

Synonyms

NOS-3, Nanos3, Nos3, Nanos C2HC-Type Zinc Finger 3, ZC2HC12C, NANOS1L

Immunogen

Recombinantproteincorrespondingto Mouse Nanos3

Isotype

IgG

Purity

Affinity purification

Predicted MW.

19 kDa

Observed MW.

19 kDa

Uniprot ID

P60324




Applications


Applications

Species

Dilution

Positive Sample

WB

Mouse, Rat

1: 500-1: 1000

testis, kidney, brain




Background


Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In Drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects.




Images


Picture 1.png

Western blot analysis of Nanos3 (GB111666) at dilution of 1: 500




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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