服務熱線
400-1016-218
聯(lián)系方式
- 手機：400-1016-218
- Q Q：355185756
- 郵箱：355185756@qq.com
- 地址：安徽省合肥市高新區(qū)黃山路602號合肥國家大學科技園A401室
Anti -NCR1 Rabbit pAb
價格：
在線咨詢
貨號：
DRF101625
產(chǎn)品規(guī)格：
100 μL
Applications：
Species：
購買數(shù)量：
產(chǎn)品詳情
操作說明
注意事項
Product Information
|
Description |
NCR1 rabbit polyclonal |
|
Protein full name |
Natural cytotoxicity triggering receptor 1 |
|
Synonyms |
Activating receptor 1, mAR-1, Lymphocyte antigen 94, Natural killer cell p46-related protein, NK-p46, NKp46, CD335, Ncr1, Ly94 |
|
Immunogen |
Recombinant protein corresponding to Mouse NCR1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
37 kDa |
|
Observed MW. |
46 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
spleen, thymus, lymph gland |
Background
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR) . These receptors are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. Mouse NKp46, also known as MAR-1 is a type I trans membrane protein with two extracellular Ig-like domains. It has a positive charge in its transmembrane domain that permits association with the ITAM-bearing signal adapter proteins, CD3 zeta and Fc epsilon RI gamma. Studies with neutralizing antibodies indicate that the three NCR are primarily responsible for triggering the NK-mediated lysis of many human tumor cell lines. Blocking any of the NCRs individually resulted in partial inhibition of tumor cell lysis, but nearly complete inhibition of lysis was observed if all three receptors were blocked simultaneously. NKp46 has also been implicated in recognition of virus-infected cells through its capacity to bind to viral hemagglutinins.
Images
|
|
IWestern blot analysis of NCR1 (GB111102) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
凡合肥萬物生物科技有限公司銷售的產(chǎn)品均有嚴格的質(zhì)量保證。如發(fā)現(xiàn)產(chǎn)品存在包裝規(guī)格疑問，請于收貨之日起七日內(nèi)向我公司總部或當?shù)剞k事處提出，并請保證該產(chǎn)品，以備本公司進行核對檢驗。如果發(fā)現(xiàn)有質(zhì)量問題，請于收貨后一月內(nèi)保留產(chǎn)品50%以上的量，以便本公司回收產(chǎn)品進行質(zhì)檢，確認產(chǎn)品質(zhì)量。如逾期，則視為已經(jīng)對本公司產(chǎn)品進行驗收。 聲明：如發(fā)生產(chǎn)品索賠事宜，本公司僅在產(chǎn)品價格范圍內(nèi)酌情賠償，恕不接受超出產(chǎn)品價格范圍之賠償。客戶在使用過程中有任何技術(shù)問題可以撥打技術(shù)售后服務電話我們隨時給予解答。
合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區(qū)黃山路602號合肥國家大學科技園A401室