Anti -RB-1 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

DRF101235

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

M/R,M/R

品牌：

萬(wàn)物

購(gòu)買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說(shuō)明注意事項(xiàng)

Product Information

Description	RB-1 rabbit polyclonal
Protein full name	Retinoblastoma-associated protein
Synonyms	pRb, Rb, pp105, Rb1
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse RB-1
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus
Uniprot ID	P13405, P33568

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1: 700-1: 1400	brain, kidney, lung, skeletal muscle
IF	Mouse, Rat	1: 500-1: 2500	brain, kidney, lung, skeletal muscle

Background

RB1 belongs to the retinoblastoma protein family. It is a key regulator of entry into cell division that acts as a tumor suppressor. RB1 acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV39H1, SUV420H1/H2, leading to epigenetic transcriptional repression. RB1 controls histone H4 'Lys-20' trimethylation and inhibits the intrinsic kinase activity of TAF1. It mediates transcriptional repression by Smarxa4/Brg1 by recruiting a histone deacetylase complex to the c-FOS promoter. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

Images

	Immunohistochemistry analysis of paraffin-embedded mouse brain using RB-1 (GB111111) at dilution of 1: 1400
	Immunohistochemistry analysis of paraffin-embedded rat brain using RB-1 (GB111111) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded rat kidney using RB-1 (GB111111) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded rat lung using RB-1 (GB111111) at dilution of 1: 1400
	Immunohistochemistry analysis of paraffin-embedded mouse skeletal muscle using RB-1 (GB111111) at dilution of 1: 1000
	Immunofluorescent analysis of paraffin-embedded mouse brain using RB-1 (GB111111) at dilution of 1: 1000
	Immunofluorescent analysis of paraffin-embedded rat brain using RB-1 (GB111111) at dilution of 1: 1000
	Immunofluorescent analysis of paraffin-embedded rat kidney using RB-1 (GB111111) at dilution of 1: 1000
	Immunofluorescent analysis of paraffin-embedded rat lung using RB-1 (GB111111) at dilution of 1: 1000
	Immunofluorescent analysis of paraffin-embedded mouse skeletal muscle using RB-1 (GB111111) at dilution of 1: 1000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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