Anti -Topoisomerase III alpha Rabbit pAb

價格：在線咨詢

貨號：

KT012130

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項

Product Information

Description	Topoisomerase III alpha rabbit polyclonal antibody
Protein full name	DNA topoisomerase 3-alpha
Synonyms	DNA topoisomerase III alpha, TOP3A, TOP3, ZGRF7, topo III-alpha, zinc finger, GRF-type containing 7, topoisomerase III alpha
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Topoisomerase III alpha
Isotype	IgG
Purity	Affinity purification
Predicted MW.	112 kDa
Observed MW.	112 kDa
Uniprot ID	Q13472

Applications

Applications	Species	Dilution	Positive Sample
WB	Human	1: 500-1: 1000	HeLa, HEK293, K562

Background

DNA topoisomerase 3-alpha (TOP3A) is an essential component of the RMI complex, a complex involves in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. It releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils.

Images

Picture 1.png

Western blot analysis of TOP3A (GB111889) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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