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Anti -NF2 / Merlin Rabbit pAb

價格: 在線咨詢
貨號:
KT011895
產(chǎn)品規(guī)格:
100ul
Applications:
IHC/IF
Species:
M/R
購買數(shù)量:
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產(chǎn)品詳情 操作說明 注意事項

Product Information


Description

NF2 rabbit polyclonal antibody

Protein full name

Merlin

Synonyms

Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomin, Schwannomin, NF2

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse NF2

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Cell Membrane, Nucleus

Uniprot ID

P46662, Q63648




Applications


Applications

Species

Dilution

Positive Sample

IHC/IF

Mouse, Rat

1: 500-1: 3000

brain, eye, heart, lung, spleen




Background


NF2 is the probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity.




Images


Immunohistochemistry of paraffin embedded mouse eye using NF2 (GB111285) at dilution of 1:1000 (400x lens)

Immunohistochemistry of paraffin embedded mouse heart using NF2 (GB111285) at dilution of 1:2000 (400x lens)

Immunohistochemistry of paraffin embedded mouse spleen using NF2 (GB111285) at dilution of 1:2000 (400x lens)

Immunohistochemistry of paraffin embedded rat heart using NF2 (GB111285) at dilution of 1:2000 (400x lens)

Immunohistochemistry of paraffin embedded rat spleen using NF2 (GB111285) at dilution of 1:2000 (400x lens)

Immunofluorescence of paraffin embedded mouse brain using NF2 (GB111285) at dilution of 1:2000 (400x lens)

Immunofluorescence of paraffin embedded mouse spleen using NF2 (GB111285) at dilution of 1:2000 (400x lens)

Immunofluorescence of paraffin embedded rat lung using NF2 (GB111285) at dilution of 1:2000 (400x lens)




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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