Anti -CD8 Rabbit pAb

價(jià)格：在線咨詢

貨號：

DRF101783

產(chǎn)品規(guī)格：

50 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	CD8 rabbit polyclonal
Protein full name	T-cell surface glycoprotein CD8 alpha chain
Synonyms	CD8A, CD8, Leu2, MAL, p32,CD8a molecule, CD8 alpha
Immunogen	Synthetic peptide within Human CD8 aa 200 to the C-terminus. The exact sequence is proprietary.
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cell membrane, Secreted
Uniprot ID	P01732

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Human	1: 200-1: 400	tonsil

Background

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

Images

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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