Anti -BLNK Rabbit pAb

價格：在線咨詢

貨號：

DRF101778

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項

Product Information

Description	BLNK rabbit polyclonal
Protein full name	B-cell linker protein
Synonyms	Blnk, AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, Bca, B-cell linker
Immunogen	Recombinant protein corresponding to Mouse BLNK
Isotype	IgG
Purity	Affinity purification
Subcellular location	Membrane
Uniprot ID	Q9QUN3, Q4KM52

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1: 3000-1: 5000	spleen
IF	Mouse, Rat	1: 1500-1: 2500	spleen

Background

The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.

Images

Immunohistochemistry analysis of paraffin-embedded mouse spleen using

BLNK (GB11734) at dilution of 1: 3000

Immunohistochemistry analysis of paraffin-embedded mouse spleen using

BLNK (GB11734) at dilution of 1: 3000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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