Anti -IL-1R-2 Rabbit pAb

價(jià)格：在線咨詢

貨號：

DRF101694

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	IL-1R-2 rabbit polyclonal
Protein full name	Interleukin-1 receptor type 2
Synonyms	IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, Interleukin 1 receptor, type II, interleukin 1 receptor type 2, IL1 Receptor II
Immunogen	Recombinant protein corresponding to Mouse IL1 Receptor II
Isotype	IgG
Purity	Affinity purification
Subcellular location	Secreted, Cell membrane
Uniprot ID	P27931

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1: 300-1: 600	pneumonia, spleen
IF	Mouse, Rat	1: 100-1: 300	pneumonia, spleen

Background

The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signalling IL-1 receptor, namely IL-1RAcP, and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

Images

Immunohistochemistry analysis of paraffin-embedded mouse pneumonia using

IL1 Receptor II (GB11603) at dilution of 1: 300

Immunohistochemistry analysis of paraffin-embedded mouse spleen using

IL1 Receptor II (GB11603) at dilution of 1: 300

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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