Anti -IL-10 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

DRF101659

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬(wàn)物

購(gòu)買數(shù)量：

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產(chǎn)品詳情操作說(shuō)明注意事項(xiàng)

Product Information

Description	IL-10 rabbit polyclonal
Protein full name	Interleukin-10
Synonyms	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10, Cytokine Synthesis Inhibitory Factor, Interleukin-10 precursor
Immunogen	Recombinant protein corresponding to Mouse IL-10
Isotype	IgG
Purity	Affinity purification
Subcellular location	Secreted
Uniprot ID	P18893, P29456

Applications

applications	species	dilution	Positive tissue
IHC	Mouse, Rat	1: 200-1: 1000	inflammatory lung, inflammatory liver, inflammatory spleen
IF	Mouse, Rat	1: 200-1: 1000	inflammatory lung, inflammatory liver, inflammatory spleen

Background

IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and Th1 T cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. IL-10 is linked to the myokines, as exercise provokes an increase in circulating levels of IL-1ra, IL-10, and sTNF-R, suggesting that physical exercise fosters an environment of anti-inflammatory cytokines.

Images

	Immunohistochemistry analysis of paraffin-embedded mouse inflammatory lung using IL-10 (GB11534) at dilution of 1: 500
	Immunohistochemistry analysis of paraffin-embedded rat inflammatory lung using IL-10 (GB11534) at dilution of 1: 500
	Immunohistochemistry analysis of paraffin-embedded rat inflammatory spleen using IL-10 (GB11534) at dilution of 1: 1000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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